Measures the total amount of protein in the blood. It also measures the amounts of two major groups of proteins in the blood: albumin and globulin. •Albumin is made mainly in the liver. It helps keep the blood from leaking out of blood vessels. Albumin also helps carry some medicines and other substances through the blood and is important for tissue growth and healing. •Globulin is made up of different proteins called alpha, beta, and gamma types. Some globulins are made by the liver, while others are made by the immune system. Certain globulins bind with hemoglobin. Other globulins transport metals, such as iron, in the blood and help fight infection. Serum globulin can be separated into several subgroups by serum protein electrophoresis. To learn more, see the topic Serum Protein Electrophoresis. A test for total serum protein reports separate values for total protein, albumin, and globulin. Some types of globulin (such as alpha-1 globulin) also may be measured. Albumin is tested to: •Check how well the liver and kidneys are working. •Find out if your diet contains enough protein. •Help determine the cause of swelling of the ankles (edema) or abdomen (ascites) or of fluid collection in the lungs that may cause shortness of breath (pulmonary edema). Globulin is tested to: •Determine your chances of developing an infection. •See if you have a blood disease, such as multiple myeloma or macroglobulinemia This test is included in the Comprehensive Metabolic Panel 14 (CMP-14) which is a panel of tests that will provide more information.